Epidemiological and genetic study of Parkinson’s disease in Quebec

Title of the Study: Epidemiological and genetic study of Parkinson’s disease in Quebec

Principal Investigator: Nicolas DUPRÉ

Co-Investigators: Guy A. ROULEAU, Mélanie LANGLOIS, Anne‐Marie DUFRESNE, Emmanuelle POURCHER, Sylvain CHOUINARD, Michel PANISSET, Edward FON, Anne‐Louise LAFONTAINE

Study sites: CHU de Québec (Enfant‐Jésus), Centre universitaire de santé McGill (Montréal), Clinique Sainte‐Anne (Québec), CHU de Montréal.

Objective of the study: The objective of this study is to determine how Environmental factors, lifestyle, medical factors and genetic variations can cause the onset of this of Parkinson’s disease. The study of these factors could help to better understand this disease and to promote better diagnotic tests and new treatments.

Specific aims :

1. Study the effect on disease risk of known or predicted susceptibility alleles in Parkinson’s disease (PD) in Quebec using cases and controls (unrelated and family-based) that are ascertained according to strict phenotypic definition, genealogy, and data collection of other contributing risk factors (environmental, medical, lifestyle).

2. Study the environmental risk factors (pesticide exposure, work history, residential history), lifestyle risk factors (coffee drinking, tea drinking, cigarette smoking, alcohol consumption, vitamin intake), and the medical risk factors (head injury, depression, oestrogen use) present in the PD population in Quebec using cases and controls (unrelated and family-based).

3. Study the familial risk of PD present in the PD population in Quebec using cases and unrelated controls.

4. Study the shared genealogy of familial and non-familial PD cases in Quebec using the BALSAC registry of Quebec genealogy.

5. Study the involvement of known genes (parkin and α-synuclein) on familial cases of PD in Quebec.