Studying the resting-state networks associated with cognitive deficits in Parkinson’s disease (PD)

Title of the study : Studying the resting-state networks associated with cognitive deficits in Parkinson’s disease (PD)

Principle Investigator : Dr. Oury Monchi

Site address : Institut Universitaire de gériatrie de Montréal, 4545 Queen Mary H3W 1W4

Abstract : It is now well established that an important fraction of persons with Parkinson Disease (PD) will develop cognitive deficits early in the disease. These deficits have been shown to be important predictors of future quality of life in the early stage of the disease. in age-matched controls. Dementia in PD (PDD) is associated with a very substantial impairment of activity in daily life and a higher rate of mortality than PD patients without dementia. The nature and evolution of cognitive deficits in PD remain poorly understood. In particular, no clinical model can explain why a proportion of PD patients decline rapidly with respect to cognition while others do not. Towards this goal, we propose to compare cognitively healthy PD patients, demented PD and patients with PD-MCI (Mild Congnitive Impairment) on measures of functional and anatomical MRI as well as clinical and behavioural ones. nature and evolution of cognitive deficits in PD remain poorly understood. In particular, no clinical model can explain why a proportion of PD patients decline rapidly with respect to cognition while others do not. Towards this goal, we propose to compare cognitively healthy PD patients, demented PD and patients with PD-MCI on measures of functional and anatomical MRI as well as clinical and behavioural ones.