Electrical brain stimulation and Impulsive control disorders

Title of the study: Effects of non – invasive electrical brain stimulation on decision-making in patients with impulse control disorders in Parkinson’s disease

Principal Investigator:  Fecteau, Shirley, Ph.D

Co-investigators: Maya, Dickler and Nicolas Dupré

Site of the study: Institut Universitaire en santé mentale  de Québec located at 2601 Chemin de la Canardière, Québec, QC G1J 2G3

Abstract: Dopaminergic treatment improves motor symptoms in patients with Parkinson’s disease (PD), but in some cases can result in impulse control disorders (ICD). Parkinson’s disease patients with ICD are characterized by deficit in decision making, such as risk taking, sensitivity to reward and an abnormally high level of impulsiveness. It seems that these deficits are associated with dysfunction of the prefrontal structures. Electrical brain stimulation could modulate cortical excitability by improving behaviors associated with stimulation.

Objective of the study : The objective of the study is to reduce the severity of decision-making deficit in PD patients with  ICD. The researchers will also study the effect of electrical brain  stimulation on the severity of the ICD and the cognitive process of risk-taking, research award and impulsivity.