Title of the project: Percpetual-Cognitive Training in PD: Impact on Cognitive Function, Mobility, Quality of Life, and Neural Mechanisms
Principle Investigator : Jocelyn Faubert, Ph.D.
Co-investigators : Oury Monchi, Ph.D., Claudine Habak
Site of the study : École d’optométrie, Université de Montréal – Clinique universitaire de la vision, 3744 Rue Jean-Brillant, Montréal, QC H3T 1P1
Abstract : Parkinson’s disease (PD) holds grave effects on quality of life, and training regimens that complement pharmacological intervention could greatly benefit PD patients. In addition, understanding the neural change involved in training-induced improvement in PD would help to optimize treatment. Perceptual-cognitive training holds known benefits in the elderly, making it clinically relevant to PD, but has not been applied in PD. This training, in healthy older populations, has yielded improvement of cognitive function and daily-task execution and has helped to maintain mobility and driving independence, with protective effects on quality of life lasting 5 years. This series of improvements is particularly important, because benefits are not limited to the perceptual-cognitive domain, but extend to general function, mobility, and quality of life. In PD, both motor and cognitive neural circuits are deficient, but medication supports mainly the motor sub-system, making complementary treatment and understanding its effects on brain activity, essential in PD.
Purpose of the study : The purpose of this project is to evaluate the effects of perceptual-cognitive training on neuropsychological measures, mobility and quality of life measures, and brain activation patterns using fMRI and Near-Infrared Spectroscopy (NIRS).