Transcranial magnetic stimulation and Cognitive effect

Study title: Cognitive effect of transcranial magnetic stimulation on patients with Parkinson’s disease and mild cognitive impairment

Principal investigator: Oury Monchi, PhD.

Co-Investigators:Dr. Marie -Andrée Bruneau et Dr. Anne- Louise Lafontaine

Site Address:  Centre de recherche de l’Institut Universitaire de Gériatrie de Montréal, 4545 Chemin Queen-Mary

Montréal, Québec, H3W 1W4

Background: Several studies have shown that transcranial magnetic stimulation (TMS), a non-invasive technique with the ability to stimulate a targeted region of the brain, could have a beneficial effect on the cognitive profile of patients with different medical conditions. However, very few studies were done in the context of Parkinson’s disease (PD). Therefore, it would be interesting to investigate whether TMS could increase cognitive performances in PD patients with mild cognitive impairment (MCI).

Purpose of the Study:Our project consists of two groups of PD-MCI patients: one group received real TMS and the other one received sham TMS. We aim to compare their performances on different cognitive tests assessing verbal learning/memory, language, executive functions, attention and visuospatial abilities.